From Harvard Law’s Dan Collis-Puro, a how-to on optimizing your WordPress MU install, using Nginx as a front-end proxy cache for WordPress:
We put an nginx caching proxy server in front of our wordpress mu install and sped it up dramatically – in some cases a thousandfold. I’ve packaged up a plugin, along with installation instructions here – WordPress Nginx proxy cache integrator.
You can read the full details on Dan’s blog and grab the plugin from the WordPress.org plugin directory.
[ Visit http://blogs.law.harvard.edu/djcp ]